Isotope Dilution Mass Spectrometry (IDMS) has become an essential tool in research laboratories and is increasingly used in routine analysis labs (including environmental, food safety and clinical applications). This is the first textbook to present a comprehensive and instructive view of the theory and applications of this growing technique.
Quantitative analysis of gibberellins by isotope dilution mass spectrometry: A comparison of the use of calibration curves, an isotope dilution fit program and …
This review highlights the main advances in the quantification of modified nucleotides and nucleosides by isotope dilution using isotopically labeled analogs combined with liquid or gas chromatography coupled to …
Isotope dilution thermal ionization mass spectrometry (ID-TIMS) is considered the "gold standard" for obtaining precise 87 Rb/ 86 Sr and 87 Sr/ 86 Sr isotope ratios and accurate elemental concentrations of Rb–Sr. However, the classical ID-TIMS technique is laborious and time-consuming because the purified Rb and Sr fractions …
Theoretical considerations in stable isotope dilution mass spectrometry for organic analysis. Anal. Chem., 48 (1976), pp. 1885-1890, 10.1021/ac50007a019. View in Scopus Google Scholar [14] B.H. Min, W.A. Garland. Determination of clonazepam and its 7-amino metabolite in plasma and blood by gas chromatography—chemical ionization …
The isotope dilution mass spectrometry (IDMS) technique is well known and widely reported in the literature. However, its application can present considerable difficulties with regard to obtaining reliable results. Produced jointly by the Royal Society of Chemistry's Analytical Methods Committee and the Valid Analytical Measurement (VAM ...
12.119: Concentration determination by isotope dilution Most concentration determinations that are done by thermal ionization mass spectrometry use the technique of isotope dilution. The basic principle of isotope dilution is that a known amount of a spike (or tracer) of known isotopic composition and elemental ...
The introductory chapter provides an overview of isotope dilution mass spectrometry, including a brief historical outline of the method. The second chapter is …
Therefore, the isotope dilution mass spectrometry (IDMS) is developed as a calibration method to eliminate the matrix effects with the addition of the known amount of isotopically labeled analogues served as internal standards [32], [33], [34].
Internal standard-based quantitation methods such as single (ID 1 MS), double (ID 2 MS), and quintuple (ID 5 MS) isotope dilution mass spectrometry, as well as external standard calibration, were explored and compared. A certified reference material (CRM) of OTA in flour, MYCO-1, was used to evaluate the accuracy of each method.
Isotope dilution analysis (IDA) or isotope dilution mass spectrometry (ID-MS) is a well-known analytical technique based on the measurement of isotope ratios in samples where the isotopic composition has been altered by the addition of a known amount of an isotopically enriched element [1]. It is an absolute
The concentration of insulin in a production vat is determined by isotope dilution. A 1.00-mg sample of insulin labeled with 14 C that has an activity of 549 cpm is added to a 10.0-mL sample taken from the production vat. After homogenizing the sample, a portion of the insulin is separated and purified, yielding 18.3 mg of pure insulin.
Isotope Dilution Mass Spectrometry For Quantitative Elemental Analysis Of Powdered Samples By Radiofrequency Pulsed Glow Discharge Time Of Flight Mass Spectrometry. Published. October 15, 2013. Author(s) John L. Molloy, Julian Malherbe, Fanny Claverie, Beatriz Fernandez, Aitor Alvarez-Toral, Alfredo Sanz-Medel, Rosario …
1. Introduction. Isotope dilution mass spectrometry (IDMS) is an established method for measuring amount of an element and, when carefully implemented, can be a primary measurement method that is traceable to the mole [[1], [2], [3]].The measurements described here represent a novel use of IDMS to precisely quantify the …
when mass spectrometry more and more evolved into an analytical technique of highest performance, this principle has been combined with mass spectrometry, which now is known as Isotope Dilution Mass Spectrometry (IDMS). An IDMS precursor has been published in biochemistry. Here the metabolism of amino acids in animals has been …
1.1 This method consists of two approaches: (1) isotope dilution mass spectrometry (IDMS) for the determination of the total concentrations of elements and molecules and (2) molecular speciated isotope dilution mass spectrometry (SIDMS) for the determination of elemental and molecular species.
Isotopically labeled standards are added in the course of DNA digestion, which allows exact quantification by isotope dilution mass spectrometry. To …
Isotope Dilution Mass Spectrometry (IDMS) has become an essential tool in research laboratories and is increasingly used in routine analysis labs (including …
International Journal of Mass Spectrometry and Ion Processes, 118/119 (1992) 575-592 575 Elsevier Soence Publishers B.V., Amsterdam Isotope dilution mass spectrometry* Klaus G. Heumann Instttut J~r Anorgamsche Chemw der Umversttat Regensburg, Umversttdtsstrasse 31, W-8400 Regensburg (Germany) (Recewed 26 …
Liquid chromatography-mass spectrometry (LC-MS) is now a routine technique with the development of electrospray ionisation (ESI) providing a simple and robust interface. ... McCoy L, Zhang M, Gunter EW. Determination of folate vitamers in human serum by stable-isotope-dilution tandem mass spectrometry and comparison with radioassay and ...
This article proposes a practical guide including good laboratory practices followed by a critical review about the application of isotope dilution mass …
These isotope dilution-based mass measurements have relative expanded uncertainties <0.1% (k ¼ 2), which will allow solution masses measured by micro-capillary and inkjet dispensing methods to be assessed for accuracy. Published by Elsevier B.V. 1. Introduction Isotope dilution mass spectrometry (IDMS) is an established
Isotope Dilution Mass Spectrometry. By Jose Alonso; Jose Alonso University of Oviedo, Spain. Search for other works by this author on: This Site. PubMed. Google Scholar. Pablo Gonzalez. Pablo Gonzalez University of Oviedo, Spain. Search for other works by this author on: This Site. PubMed ...
The isotope dilution mass spectrometry (IDMS) technique is well known and widely reported in the literature. However, its application can present considerable …
Isotope dilution mass spectrometry (IDMS) of the elements. Klaus G. Heumann, Klaus G. Heumann. Institut für Anorganische Chemie der Universität Regensburg, Universitätsstrasse 31, D-8400 Regensburg, …
Isotopically labeled standards are added in the course of DNA digestion, which allows exact quantification by isotope dilution mass spectrometry. To overcome the major bottleneck of such analyses, we developed a short (~14-min-per-sample) ultra-HPLC (UHPLC) and triple quadrupole mass spectrometric (QQQ-MS) method. Easy calculation of the ...
Objectives: This study was designed to improve our previously developed tandem mass spectrometry (MS/MS) method for free thyroxine (FT4) by enhancing sensitivity and permitting simultaneous measurements of both free triidothyronine (FT3) and FT4 using a smaller plasma/serum sample. Design and methods: An API-5,000 tandem mass …
Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides Franziska R. Traube 1,2, Sarah Schiffers 1,2, Katharina Iwan 1,2, Stefanie Kellner 1, Fabio Spada 1,
This article proposes a practical guide including good laboratory practices followed by a critical review about the application of isotope dilution mass spectrometry (ID-MS) measurement to radionuclide analyses. Several national and international scientific institutions (French Alternative Energies and Atomi
Isotope dilution is an essential technique employed in a wide array of geochemical studies, providing both highly accurate and precise elemental …
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